Future Shadowrun campaign

Over the summer I will be GMing a Shadowrun game. The story takes place in and around Las Vegas, and is focused on investigating and eventually toppling a very powerful drug dealer. There will be only three players (there was a fourth, but he decided to accept a work placement scheme in London instead. Talk about poor priorities!), so I'm throwing in a couple of NPCs as well.

The story will start with all of the characters awakening and finding themselves in a small room, which looks very much like a high-security prison cell (mostly because it is a high-security prison cell). They all have envelopes in front of them with various instructions on how to escape which will only work when combined. With any luck they will escape the prison, and will then have to find their way to Las Vegas, the nearest city, whereupon Mr Johnson (for those of you who aren't Shadowrunners, "Mr. Johnson" always refers to a person who hires shadowrunners, in order to disguise whatever their true identity is) will contact them, and offer them a job. Although they don't know it, he was in fact the one who put them into the jail cell.

The job he offers them is to take down a local drug dealer and shut down his operation. It isn't a difficult job, but if the players dig a little deeper into the situation, they will find a tangled web of evidence suggesting that Mr. Johnson himself is the one who supplied the dealer. Either way, Mr. Johnson will continue to give them jobs of various kinds, one of which will bring them into contact with a group who claim that Mr. Johnson is poised to betray them. Whether or not they beleive these people, they will soon find themselves attacked by thugs.

Various things happen and, with a dash of luck, the campaign will end with the overthrow of Mr. Johnson's operation. He may or may not be the 'final boss'. Of course, players have a nasty habit of throwing your plot off course, so I have a few sidequests prepared for if such a thing should happen, which will give me time to prepare.

More on this as it comes in.